1.Structural and Functional Mechanisms of Membrane Proteins Related to Major Human Diseases

Membrane proteins are critical proteins located in biological cell membranes, playing essential roles in maintaining the balance of the internal and external cellular environment, signal transduction, and substance transport. Many major human diseases, such as cancer, cardiovascular diseases, and neurological disorders, are closely associated with abnormalities in the structure or function of membrane proteins. A deeper understanding of the structural and functional mechanisms of membrane proteins can help reveal the molecular mechanisms underlying these diseases, providing a foundation for early diagnosis, treatment, and drug design. Additionally, targeted drugs can be developed to intervene in abnormal protein functions and restore normal cellular activity.

2.Bacterial Antibiotic Resistance and Novel Antimicrobial Targets

Gram-negative bacteria, such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae, are common multi-drug resistant pathogens that pose serious threats to human health. These "superbugs" present significant challenges for clinical treatments, creating an urgent need for the development of novel antimicrobial drugs. The unique biofilm structure of Gram-negative bacteria acts as a protective barrier, hindering the entry of antibiotics and other substances into the cells. Disrupting the stability of the biofilm can compromise bacterial survival. The biofilm of Gram-negative bacteria is composed of functional components such as lipopolysaccharides, phospholipids, peptidoglycan, outer membrane β-barrel proteins, and lipoproteins. The transport and correct localization of these essential components are key to maintaining biofilm stability and are crucial for bacterial survival. Therefore, targeting the stability of biofilms in antibiotic-resistant Gram-negative bacteria presents a promising novel antibiotic strategy.

3.Development and Application of Antibodies, Peptides, Vaccines, and Drugs for Infectious Diseases 

Infectious diseases, caused by pathogens such as bacteria, viruses, fungi, and parasites, pose significant threats to human health and global public health. The development and application of antibodies, peptides, vaccines, and drugs are key strategies for preventing and treating infectious diseases. These approaches aim to rapidly identify pathogens and intervene in their activity, thereby blocking infection transmission, controlling disease progression, and improving patient outcomes.